In the creatinine clearance calculation example, the calculated clearance was approximately which value in mL/min?

In the creatinine clearance calculation example, the calculated clearance was approximately which value in mL/min?

• A. 11
• B. 63
• C. 95
• D. 106

Answer: (D)

This question tests how creatinine clearance is used to estimate glomerular filtration rate (GFR). Creatinine clearance is calculated with the formula: clearance = (urine creatinine concentration × urine flow rate) / plasma creatinine concentration. It reflects how effectively the kidneys are filtering creatinine from the blood. In the example, plugging in the urine creatinine, urine flow, and plasma creatinine values gives a result near 106 mL/min. This sits in the normal range for adult GFR, which is roughly 90–120 mL/min. A clearance around 106 mL/min indicates near-normal filtration capacity. If the calculation yielded values much lower, like around 63 or 11 mL/min, that would suggest impaired kidney function. A result around 95 mL/min would also be consistent with normal function, but 106 mL/min is a typical demonstration value that closely matches the standard normal range.

This question tests how creatinine clearance is used to estimate glomerular filtration rate (GFR). Creatinine clearance is calculated with the formula: clearance = (urine creatinine concentration × urine flow rate) / plasma creatinine concentration. It reflects how effectively the kidneys are filtering creatinine from the blood.

In the example, plugging in the urine creatinine, urine flow, and plasma creatinine values gives a result near 106 mL/min. This sits in the normal range for adult GFR, which is roughly 90–120 mL/min. A clearance around 106 mL/min indicates near-normal filtration capacity.

If the calculation yielded values much lower, like around 63 or 11 mL/min, that would suggest impaired kidney function. A result around 95 mL/min would also be consistent with normal function, but 106 mL/min is a typical demonstration value that closely matches the standard normal range.